|
rs9940128
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of FL</span>D among rs9940128 AA carriers was 55.7% (63 of 113 individuals) and that in patients without this genotype was 39.7% (204 of 514 individuals) [P = 0.009; adjusted odds ratio 1.88; 95% confidence interval (CI) 1.17-3.01].
|
28116842 |
2017 |
|
rs9939609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (rs8050136, rs9939609 and rs9940128) were associated with FLD, with rs9940128 showing the strongest association.
|
28116842 |
2017 |
|
rs951599607
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genetic polymorphism I148M of the patatin-like phospholipase domain-containing 3 (PNPLA3) is associated with hepatic steatosis and its progression to steatohepatitis (NASH), fibrosis and cancer.
|
29116096 |
2017 |
|
rs926633
|
|
|
0.700 |
GeneticVariation |
GWASDB |
The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.
|
23477746 |
2013 |
|
rs903361
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>ADORA1</i> rs903361 associated with resolution of NASH (<i>p</i> = 0.0005) and change in the ballooning score among Caucasian and Hispanic patients (<i>p</i> = 0.0005).
|
30065651 |
2018 |
|
rs8192678
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, there was an additive effect of the PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype on the presence of NASH (OR 6.83; 95% CI 1.61-29.01; P = 0.009).The PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype had an additive effect on NASH in severely obese Taiwanese patients.
|
27015186 |
2016 |
|
rs8050136
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (rs8050136, rs9939609 and rs9940128) were associated with FLD, with rs9940128 showing the strongest association.
|
28116842 |
2017 |
|
rs7946
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Val175Met variant of PEMT could be a candidate molecule that determines the susceptibility to NASH, because it is more frequently observed in NASH patients and non-obese persons with Val175Met variant of PEMT are facilitated to develop NASH.
|
17391797 |
2007 |
|
rs7946
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Decreased liver PC content in individuals with the NASH is independent of PEMT V175M genotype and could be partly linked to decreased GNMT expression.
|
31199045 |
2019 |
|
rs780094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that risk allele T of the GCKR rs780094 and rs1260326 is associated with predisposition to NAFLD and NASH with significant fibrosis.
|
23800943 |
2014 |
|
rs7643645
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, in univariate analysis rs7643645/G was significantly associated with fatty liver disease (P<0.04), with an odds ratio of 1.457 (95% confidence interval: 1.018-2.086).
|
19940802 |
2010 |
|
rs738491
|
|
|
0.710 |
GeneticVariation |
GWASDB |
The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.
|
23477746 |
2013 |
|
rs738491
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The rs12743824 and rs738491 SNPs were independently associated with FLD and steatohepatitis, respectively.
|
26352879 |
2015 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Association studies confirm that the I148M polymorphism is also a strong modifier of NASH and progressive hepatic injury.
|
23394097 |
2013 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, the rs738409 G allele is associated with severity of NASH and occurrence of fibrosis in patients with NAFLD.
|
22258181 |
2012 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The genetic polymorphism I148M of the patatin-like phospholipase domain-containing 3 (PNPLA3) is associated with hepatic steatosis and its progression to steatohepatitis (NASH), fibrosis and cancer.
|
29116096 |
2017 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recently, genome-wide association studies led to the identification of the major inherited determinants of hepatic fat accumulation: patatin-like phospholipase domain-containing 3 (PNPLA3) I148M gene and transmembrane 6 superfamily member 2 (TM6SF2) E167K gene variants, involved in lipid droplets remodelling and very low-density lipoproteins secretion, are the major determinants of interindividual differences in liver steatosis, and susceptibility to progressive NASH.
|
26273621 |
2015 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Reduced adiponectin is implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH), and the I148M Patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism predisposes to NAFLD and liver damage progression in NASH and chronic hepatitis C (CHC) by still undefined mechanisms, possibly involving regulation of adipose tissue function.
|
22898488 |
2012 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
To develop an animal model of PNPLA3-induced fatty liver disease, we generated transgenic mice that overexpress similar amounts of wild-type PNPLA3 (PNPLA3(WT)) or mutant PNPLA3 (PNPLA3(I148M)) either in liver or adipose tissue.
|
23023705 |
2012 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Further, there was an additive effect of the PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype on the presence of NASH (OR 6.83; 95% CI 1.61-29.01; P = 0.009).The PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype had an additive effect on NASH in severely obese Taiwanese patients.
|
27015186 |
2016 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Previously, we identified a variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) that is strongly associated with FLD, but the mechanistic basis for the association remains elusive.
|
31019090 |
2019 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A missense variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) confers susceptibility to FLD, although the mechanism is not known.
|
29555681 |
2018 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In this study, we report the association of the rs738407, rs738409, and rs2896019 variants of the patatin-like phospholipase domain-containing protein 3 (PNPLA3) (adiponutrin) gene with nonalcoholic steatohepatitis (NASH) (χ(2)=14.528, p=0.001; χ(2)=18.882, p=0.000; χ(2)=7.449, p=0.024, respectively) in 80 patients with NASH and 303 healthy controls.
|
24831885 |
2014 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
PNPLA3 rs738409 polymorphism is associated with fatty liver disease, alcoholic or non-alcoholic (NAFLD) and hepatocellular carcinoma (HCC).
|
26493626 |
2016 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Several recent genome-wide association studies have reported an association between single-nucleotide polymorphism rs738409 in the (patatin-like phospholipase domain-containing protein 3) PNPLA3 gene and FLD.
|
22546774 |
2013 |